Stromal Cell-Derived Factor-1 chemokine genetic polymorphism in hepatitis B patients Polimorfismo genético da quimiocina Fator Derivado do Estroma da medula óssea em pacientes com hepatite B

Hepatitis B virus (HBV) is noncytopathic, hepatotropic and cause acute and chronic necroinflammatory liver diseases. Many chemokine and yours receptors are involved in the HBV pathogenesis, with a role at the infection capacity and the host response. Sequence analysis of a common variant revealed a G→A transition at position 801 (counting from the ATG start codon) in the 3’ untranslated region (3’ UTR) of the reference sequence (GenBank L36033) consist the polymorphism designated SDF1-3’UTR-801 G→A and abbreviated SDF13’A which is represented in the SDF-1β but not in the SDF-1α transcript. The objective of this study was to evaluate the genotype of patients infected with HBV through a PCR-RFLP. The present study focuses the same distribution of the SDF-1 allele in the HBV positive and negative individuals.